1,5 Over the last decade, the reliability of these thresholds has been called into question. Historically, these criteria were based on small studies a CRL of ≥ 5mm and mean sac diameter of≥ 16-17 mm without an embryo were considered diagnostic for an early pregnancy loss. Ultrasonography (usually transvaginal) in combination with β-hCG and clinical history is instrumental for making the diagnosis of a nonviable pregnancy with certainty. 1-3 With the adoption of early home pregnancy testing, women are commonly referred for sonographic evaluations very early in gestation to determine pregnancy location and viability.Īlthough we believe ultrasound to be indispensable for the management of suspected early pregnancy failure, if performed too early or without strict adherence to guidelines, it may lead to inconclusive results or an incorrect diagnosis of an early pregnancy loss. The cessation of development occurs in approximately 10 percent to 20 percent of clinically recognized pregnancies, increasing with advancing parental age. This story originally appeared in Diagnostic Imaging's sister site, Contemporary Ob/GynĮarly pregnancy loss (miscarriage) is defined as a nonviable, intrauterine pregnancy with either an empty gestational sac or a gestational sac containing an embryo or fetus without cardiac activity within the first 12 6/7 weeks of gestation.
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